Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data
Abstract Background Metallo-β-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and lack of clinically useful inhibitors, ma...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2017-10-01
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Series: | Microbiome |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40168-017-0353-8 |