Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data

Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data

Abstract Background Metallo-β-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and lack of clinically useful inhibitors, ma...

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Bibliographic Details
Main Authors: Fanny Berglund, Nachiket P. Marathe, Tobias Österlund, Johan Bengtsson-Palme, Stathis Kotsakis, Carl-Fredrik Flach, D G Joakim Larsson, Erik Kristiansson
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Microbiome
Subjects:
β-lactam resistance
Carbapenemases
Shotgun metagenomics
Resistome
Hidden Markov model
Online Access:http://link.springer.com/article/10.1186/s40168-017-0353-8

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http://link.springer.com/article/10.1186/s40168-017-0353-8

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