Benzodiazepines Drive Alteration of Chromatin at the Integrated HIV-1 LTR

Benzodiazepines Drive Alteration of Chromatin at the Integrated HIV-1 LTR

Antiretroviral therapy (ART) lowers human immunodeficiency virus type 1 (HIV-1) viral load to undetectable levels, but does not eliminate the latent reservoir. One of the factors controlling the latent reservoir is transcriptional silencing of the integrated HIV-1 long terminal repeat (LTR). The mol...

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Bibliographic Details
Main Authors: Weam Elbezanti, Angel Lin, Alexis Schirling, Alexandria Jackson, Matthew Marshall, Rachel Van Duyne, Frank Maldarelli, Luca Sardo, Zachary Klase
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Viruses
Subjects:
hiv-1 transcription
viral transcription
benzodiazepines
chromatin
alprazolam
stat5
runx1
Online Access:https://www.mdpi.com/1999-4915/12/2/191

Internet

https://www.mdpi.com/1999-4915/12/2/191

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