A pyruvate carbon flux tugging strategy for increasing 2,3-butanediol production and reducing ethanol subgeneration in the yeast Saccharomyces cerevisiae

A pyruvate carbon flux tugging strategy for increasing 2,3-butanediol production and reducing ethanol subgeneration in the yeast Saccharomyces cerevisiae

Abstract Background The yeast Saccharomyces cerevisiae is a promising host cell for producing a wide range of chemicals. However, attempts to metabolically engineer Crabtree-positive S. cerevisiae invariably face a common issue: how to reduce dominant ethanol production. Here, we propose a yeast met...

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Bibliographic Details
Main Authors: Jun Ishii, Keisuke Morita, Kengo Ida, Hiroko Kato, Shohei Kinoshita, Shoko Hataya, Hiroshi Shimizu, Akihiko Kondo, Fumio Matsuda
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Biotechnology for Biofuels
Subjects:
Pyruvate flux
Crabtree effect
Acetolactate synthase
Ethanol subgeneration
2,3-Butanediol production
Pyruvate decarboxylase (PDC) deficient
Online Access:http://link.springer.com/article/10.1186/s13068-018-1176-y

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http://link.springer.com/article/10.1186/s13068-018-1176-y

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