Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia

Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia

Macrophages in the atheroma region produce matrix metalloproteinases (MMPs) and decrease plaque stability. Tissue oxygen tension decreases in the arterial wall of the atherosclerotic region. Hypoxia inducible factor (HIF)-1α plays a critical role in the transcriptional activation of hypoxia inducibl...

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Bibliographic Details
Main Authors: Shuoyu Wei, Takayuki Isagawa, Masamichi Eguchi, Daisuke Sato, Hiroto Tsukano, Keishi Miyata, Yuichi Oike, Norihiko Takeda, Satoshi Ikeda, Hiroaki Kawano, Koji Maemura
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomedicines
Subjects:
hypoxia
macrophage
matrix metalloproteinase
atherosclerotic plaque rupture
oxidative stress
xanthine oxidase
Online Access:https://www.mdpi.com/2227-9059/8/11/470

Internet

https://www.mdpi.com/2227-9059/8/11/470

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