Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accompanied by significant neuronal loss in the experimental autoim...

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Bibliographic Details
Main Authors: Feng Mei, Klaus Lehmann-Horn, Yun-An A Shen, Kelsey A Rankin, Karin J Stebbins, Daniel S Lorrain, Kara Pekarek, Sharon A Sagan, Lan Xiao, Cory Teuscher, H-Christian von Büdingen, Jürgen Wess, J Josh Lawrence, Ari J Green, Stephen PJ Fancy, Scott S Zamvil, Jonah R Chan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
demyelination
myelination
oligodendrocytes
Online Access:https://elifesciences.org/articles/18246

Internet

https://elifesciences.org/articles/18246

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