Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors
BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes.
Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12348 |