Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors
BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes.
Bibliographic Details
Main Authors: |
Helena Escuin-Ordinas,
Shuoran Li,
Michael W. Xie,
Lu Sun,
Willy Hugo,
Rong Rong Huang,
Jing Jiao,
Felipe Meira de-Faria,
Susan Realegeno,
Paige Krystofinski,
Ariel Azhdam,
Sara Marie D. Komenan,
Mohammad Atefi,
Begoña Comin-Anduix,
Matteo Pellegrini,
Alistair J. Cochran,
Robert L. Modlin,
Harvey R. Herschman,
Roger S. Lo,
William H. McBride,
Tatiana Segura,
Antoni Ribas |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2016-08-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms12348
|