Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors
BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12348 |
| id |
doaj-4df7cfd06ae5433d88273671aa9365b6 |
|---|---|
| record_format |
Article |
| spelling |
doaj-4df7cfd06ae5433d88273671aa9365b62021-05-11T10:49:27ZengNature Publishing GroupNature Communications2041-17232016-08-017111010.1038/ncomms12348Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitorsHelena Escuin-Ordinas0Shuoran Li1Michael W. Xie2Lu Sun3Willy Hugo4Rong Rong Huang5Jing Jiao6Felipe Meira de-Faria7Susan Realegeno8Paige Krystofinski9Ariel Azhdam10Sara Marie D. Komenan11Mohammad Atefi12Begoña Comin-Anduix13Matteo Pellegrini14Alistair J. Cochran15Robert L. Modlin16Harvey R. Herschman17Roger S. Lo18William H. McBride19Tatiana Segura20Antoni Ribas21Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA)Department of Chemical and Biomolecular Engineering, University of California, Los Angeles (UCLA)Division of Experimental Radiation Oncology, Department of Radiation Oncology, University of California, Los Angeles (UCLA)Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA)Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA)Department of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA)Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA)Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA)Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles (UCLA)Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA)Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA)Division of Surgical Oncology, Department of SurgeryDivision of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA)Division of Surgical Oncology, Department of SurgeryDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles (UCLA)Department of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA)Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA)Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA)Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA)Division of Experimental Radiation Oncology, Department of Radiation Oncology, University of California, Los Angeles (UCLA)Department of Chemical and Biomolecular Engineering, University of California, Los Angeles (UCLA)Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA)BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes.https://doi.org/10.1038/ncomms12348 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Helena Escuin-Ordinas Shuoran Li Michael W. Xie Lu Sun Willy Hugo Rong Rong Huang Jing Jiao Felipe Meira de-Faria Susan Realegeno Paige Krystofinski Ariel Azhdam Sara Marie D. Komenan Mohammad Atefi Begoña Comin-Anduix Matteo Pellegrini Alistair J. Cochran Robert L. Modlin Harvey R. Herschman Roger S. Lo William H. McBride Tatiana Segura Antoni Ribas |
| spellingShingle |
Helena Escuin-Ordinas Shuoran Li Michael W. Xie Lu Sun Willy Hugo Rong Rong Huang Jing Jiao Felipe Meira de-Faria Susan Realegeno Paige Krystofinski Ariel Azhdam Sara Marie D. Komenan Mohammad Atefi Begoña Comin-Anduix Matteo Pellegrini Alistair J. Cochran Robert L. Modlin Harvey R. Herschman Roger S. Lo William H. McBride Tatiana Segura Antoni Ribas Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors Nature Communications |
| author_facet |
Helena Escuin-Ordinas Shuoran Li Michael W. Xie Lu Sun Willy Hugo Rong Rong Huang Jing Jiao Felipe Meira de-Faria Susan Realegeno Paige Krystofinski Ariel Azhdam Sara Marie D. Komenan Mohammad Atefi Begoña Comin-Anduix Matteo Pellegrini Alistair J. Cochran Robert L. Modlin Harvey R. Herschman Roger S. Lo William H. McBride Tatiana Segura Antoni Ribas |
| author_sort |
Helena Escuin-Ordinas |
| title |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| title_short |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| title_full |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| title_fullStr |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| title_full_unstemmed |
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors |
| title_sort |
cutaneous wound healing through paradoxical mapk activation by braf inhibitors |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-08-01 |
| description |
BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes. |
| url |
https://doi.org/10.1038/ncomms12348 |
| work_keys_str_mv |
AT helenaescuinordinas cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT shuoranli cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT michaelwxie cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT lusun cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT willyhugo cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT rongronghuang cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT jingjiao cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT felipemeiradefaria cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT susanrealegeno cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT paigekrystofinski cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT arielazhdam cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT saramariedkomenan cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT mohammadatefi cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT begonacominanduix cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT matteopellegrini cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT alistairjcochran cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT robertlmodlin cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT harveyrherschman cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT rogerslo cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT williamhmcbride cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT tatianasegura cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors AT antoniribas cutaneouswoundhealingthroughparadoxicalmapkactivationbybrafinhibitors |
| _version_ |
1721447495963246592 |