Targeting neurons in the gastrointestinal tract to treat Parkinson's disease

Targeting neurons in the gastrointestinal tract to treat Parkinson's disease

Background: Parkinson's disease (PD) is associated with α-synuclein (αS) aggregation within the enteric nervous system (ENS) and constipation. Squalamine displaces proteins that are electrostatically bound to intracellular membranes and through this mechanism suppresses aggregation of αS monome...

Full description

Bibliographic Details
Main Authors: Robert A. Hauser, Dean Sutherland, Juan A. Madrid, Maria Angeles Rol, Steven Frucht, Stuart Isaacson, Fernando Pagan, Brian N. Maddux, George Li, Winona Tse, Benjamin L. Walter, Rajeev Kumar, Daniel Kremens, Mark F. Lew, Aaron Ellenbogen, Odinachi Oguh, Alberto Vasquez, William Kinney, Matt Lowery, Maria Resnick, Nicole Huff, Jerry Posner, Karla V. Ballman, Brian E. Harvey, Michael Camilleri, Michael Zasloff, Denise Barbut
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Clinical Parkinsonism & Related Disorders
Subjects:
Squalamine
ENT-01
Parkinson's disease
Constipation
Treatment
Non-motor
Online Access:http://www.sciencedirect.com/science/article/pii/S2590112519300015

Internet

http://www.sciencedirect.com/science/article/pii/S2590112519300015

Similar Items