Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

Glucocorticoid receptor (GR) regulates immunity and inflammation but the mechanisms by which GR represses proinflammatory genes are still being debated. Here the authors use a multidisciplinary approach and show that GR binds to a cryptic site within genome-wide NFκB DNA response elements to repress...

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Bibliographic Details
Main Authors: William H. Hudson, Ian Mitchelle S. de Vera, Jerome C. Nwachukwu, Emily R. Weikum, Austin G. Herbst, Qin Yang, David L. Bain, Kendall W. Nettles, Douglas J. Kojetin, Eric A. Ortlund
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03780-1

Internet

https://doi.org/10.1038/s41467-018-03780-1

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