Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin

The mechanisms behind the high invasiveness of Streptococcus pneumoniae serotype 1 are unclear. Here, Jacques et al. show that this feature is due to overproduction and rapid release of pneumolysin, which induces cytotoxicity and breakdown of tight junctions, allowing rapid bacterial dissemination f...

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Bibliographic Details
Main Authors: Laura C. Jacques, Stavros Panagiotou, Murielle Baltazar, Madikay Senghore, Shadia Khandaker, Rong Xu, Laura Bricio-Moreno, Marie Yang, Christopher G. Dowson, Dean B. Everett, Daniel R. Neill, Aras Kadioglu
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15751-6

Internet

https://doi.org/10.1038/s41467-020-15751-6

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