Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin

The mechanisms behind the high invasiveness of Streptococcus pneumoniae serotype 1 are unclear. Here, Jacques et al. show that this feature is due to overproduction and rapid release of pneumolysin, which induces cytotoxicity and breakdown of tight junctions, allowing rapid bacterial dissemination f...

Full description

Bibliographic Details
Main Authors:	Laura C. Jacques, Stavros Panagiotou, Murielle Baltazar, Madikay Senghore, Shadia Khandaker, Rong Xu, Laura Bricio-Moreno, Marie Yang, Christopher G. Dowson, Dean B. Everett, Daniel R. Neill, Aras Kadioglu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15751-6

id	doaj-4e3fa97f73434e33a5cdb4df33c7b5d6
record_format	Article
spelling	doaj-4e3fa97f73434e33a5cdb4df33c7b5d62021-05-11T08:20:34ZengNature Publishing GroupNature Communications2041-17232020-04-0111111310.1038/s41467-020-15751-6Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysinLaura C. Jacques0Stavros Panagiotou1Murielle Baltazar2Madikay Senghore3Shadia Khandaker4Rong Xu5Laura Bricio-Moreno6Marie Yang7Christopher G. Dowson8Dean B. Everett9Daniel R. Neill10Aras Kadioglu11Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of LiverpoolDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of LiverpoolDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of LiverpoolMedical Research Council Unit, The GambiaDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of LiverpoolDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of LiverpoolDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of LiverpoolDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of LiverpoolSchool of Life Sciences, University of WarwickMalawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi, College of MedicineDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of LiverpoolDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of LiverpoolThe mechanisms behind the high invasiveness of Streptococcus pneumoniae serotype 1 are unclear. Here, Jacques et al. show that this feature is due to overproduction and rapid release of pneumolysin, which induces cytotoxicity and breakdown of tight junctions, allowing rapid bacterial dissemination from the respiratory tract into the blood.https://doi.org/10.1038/s41467-020-15751-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Laura C. Jacques Stavros Panagiotou Murielle Baltazar Madikay Senghore Shadia Khandaker Rong Xu Laura Bricio-Moreno Marie Yang Christopher G. Dowson Dean B. Everett Daniel R. Neill Aras Kadioglu
spellingShingle	Laura C. Jacques Stavros Panagiotou Murielle Baltazar Madikay Senghore Shadia Khandaker Rong Xu Laura Bricio-Moreno Marie Yang Christopher G. Dowson Dean B. Everett Daniel R. Neill Aras Kadioglu Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin Nature Communications
author_facet	Laura C. Jacques Stavros Panagiotou Murielle Baltazar Madikay Senghore Shadia Khandaker Rong Xu Laura Bricio-Moreno Marie Yang Christopher G. Dowson Dean B. Everett Daniel R. Neill Aras Kadioglu
author_sort	Laura C. Jacques
title	Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
title_short	Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
title_full	Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
title_fullStr	Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
title_full_unstemmed	Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
title_sort	increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-04-01
description	The mechanisms behind the high invasiveness of Streptococcus pneumoniae serotype 1 are unclear. Here, Jacques et al. show that this feature is due to overproduction and rapid release of pneumolysin, which induces cytotoxicity and breakdown of tight junctions, allowing rapid bacterial dissemination from the respiratory tract into the blood.
url	https://doi.org/10.1038/s41467-020-15751-6
work_keys_str_mv	AT lauracjacques increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT stavrospanagiotou increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT muriellebaltazar increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT madikaysenghore increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT shadiakhandaker increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT rongxu increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT laurabriciomoreno increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT marieyang increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT christophergdowson increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT deanbeverett increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT danielrneill increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin AT araskadioglu increasedpathogenicityofpneumococcalserotype1isdrivenbyrapidautolysisandreleaseofpneumolysin
_version_	1721450886908084224

Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin

Similar Items