Therapeutic potential of the translation inhibitor silvestrol in hepatocellular cancer.

Although hepatocellular cancers (HCC) frequently arise in the setting of fibrosis and a hepatic regenerative response requiring new cell growth, therapeutic strategies for these cancers have not targeted protein synthesis. Silvestrol, a rocaglate isolated from Aglaiafoveolata, can inhibit protein sy...

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Bibliographic Details
Main Authors: Takayuki Kogure, A Douglas Kinghorn, Irene Yan, Brad Bolon, David M Lucas, Michael R Grever, Tushar Patel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3784426?pdf=render