Role of the microbiota in ileitis of a mouse model of inflammatory bowel disease—Glutathione peroxide isoenzymes 1 and 2‐double knockout mice on a C57BL background

Role of the microbiota in ileitis of a mouse model of inflammatory bowel disease—Glutathione peroxide isoenzymes 1 and 2‐double knockout mice on a C57BL background

Abstract C57Bl6 (B6) mice devoid of glutathione peroxidases 1 and 2 (Gpx1/2‐DKO) develop ileitis after weaning. We previously showed germ‐free Gpx1/2‐DKO mice of mixed B6.129 background did not develop ileocolitis. Here, we examine the composition of the ileitis provoking microbiota in B6 Gpx1/2‐DKO...

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Bibliographic Details
Main Authors: Fong‐Fong Chu, R. Steven Esworthy, Binghui Shen, James H. Doroshow
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:MicrobiologyOpen
Subjects:
IBD
ileitis
Lactobacillus
microbiome
mouse model
reactive oxygen species
Online Access:https://doi.org/10.1002/mbo3.1107

Internet

https://doi.org/10.1002/mbo3.1107

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