IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.

IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.

Patients with metastatic or recurrent and refractory sarcomas have a dismal prognosis. Therefore, new targeted therapies are urgently needed. This study was designed to evaluate chimeric antigen receptor (CAR) T cells targeting the type I insulin-like growth factor receptor (IGF1R) or tyrosine kinas...

Full description

Bibliographic Details
Main Authors: Xin Huang, Haein Park, Joseph Greene, James Pao, Erin Mulvey, Sophia X Zhou, Catherine M Albert, Fred Moy, Deepali Sachdev, Douglas Yee, Christoph Rader, Carl V Hamby, David M Loeb, Mitchell S Cairo, Xianzheng Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4501840?pdf=render

Internet

http://europepmc.org/articles/PMC4501840?pdf=render

Similar Items