Fifteen Years of Sm-p80-Based Vaccine Trials in Nonhuman Primates: Antibodies From Vaccinated Baboons Confer Protection in vivo and in vitro From Schistosoma mansoni and Identification of Putative Correlative Markers of Protection

Fifteen Years of Sm-p80-Based Vaccine Trials in Nonhuman Primates: Antibodies From Vaccinated Baboons Confer Protection in vivo and in vitro From Schistosoma mansoni and Identification of Putative Correlative Markers of Protection

Recent advances in systems biology have shifted vaccine development from a largely trial-and-error approach to an approach that promote rational design through the search for immune signatures and predictive correlates of protection. These advances will doubtlessly accelerate the development of a va...

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Bibliographic Details
Main Authors: Weidong Zhang, Loc Le, Gul Ahmad, Adebayo J. Molehin, Arif J. Siddiqui, Workineh Torben, Souvik Karmakar, Juan U. Rojo, Souad Sennoune, Samara Lazarus, Sabiha Khatoon, Jasmin Freeborn, Justin Sudduth, Ashraf F. Rezk, David Carey, Roman F. Wolf, James F. Papin, Ray Damian, Sean A. Gray, Florian Marks, Darrick Carter, Afzal A. Siddiqui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
Schistosoma mansoni
schistosomiasis
baboons
Sm-p80 vaccine
systems biology
transcriptomics
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01246/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01246/full

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