TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes.

by Paul F McKay, Deborah F L King, Jamie F S Mann, Guillermo Barinaga, Darrick Carter, Robin J Shattock
Published 2016-01-01

Sm-p80-based schistosomiasis vaccine mediated epistatic interactions identified potential immune signatures for vaccine efficacy in mice and baboons.

by Juan U Rojo, Michael W Melkus, Kameswara Rao Kottapalli, Oscar E Okiya, Justin Sudduth, Weidong Zhang, Adebayo J Molehin, Darrick Carter, Afzal A Siddiqui
Published 2017-01-01

Clinical adjuvant combinations stimulate potent B-cell responses in vitro by activating dermal dendritic cells.

by Katie Matthews, Nancy P Y Chung, Per Johan Klasse, Magda Moutaftsi, Darrick Carter, André M Salazar, Steven G Reed, Rogier W Sanders, John P Moore
Published 2013-01-01

Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.

by Mauricio A Arias, Griet A Van Roey, John S Tregoning, Magdalini Moutaftsi, Rhea N Coler, Hillarie P Windish, Steven G Reed, Darrick Carter, Robin J Shattock
Published 2012-01-01

Glucopyranosyl lipid A adjuvant significantly enhances HIV specific T and B cell responses elicited by a DNA-MVA-protein vaccine regimen.

by Paul F McKay, Alethea V Cope, Jamie F S Mann, Sarah Joseph, Mariano Esteban, Roger Tatoud, Darrick Carter, Steven G Reed, Jonathan Weber, Robin J Shattock
Published 2014-01-01

Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine

by Sunita Gulati, Michael W. Pennington, Andrzej Czerwinski, Darrick Carter, Bo Zheng, Nancy A. Nowak, Rosane B. DeOliveira, Jutamas Shaughnessy, George W. Reed, Sanjay Ram, Peter A. Rice
Published 2019-11-01

Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic

by Maximilian Richter, Roma Yumul, Kamola Saydaminova, Hongjie Wang, Michael Gough, Audrey Baldessari, Roberto Cattaneo, Frank Lee, Chung-Huei Katherine Wang, Haishan Jang, Anne Astier, Ajay Gopal, Darrick Carter, André Lieber
Published 2016-01-01

Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin

by Maximilian Richter, Roma Yumul, Hongjie Wang, Kamola Saydaminova, Martin Ho, Drew May, Audrey Baldessari, Michael Gough, Charles Drescher, Nicole Urban, Steve Roffler, Chloé Zubieta, Darrick Carter, Pascal Fender, André Lieber
Published 2015-01-01

Protein Microarray Analysis of the Specificity and Cross-Reactivity of Influenza Virus Hemagglutinin-Specific Antibodies

by Rie Nakajima, Medalyn Supnet, Algis Jasinskas, Aarti Jain, Omid Taghavian, Joshua Obiero, Donald K. Milton, Wilbur H. Chen, Michael Grantham, Richard Webby, Florian Krammer, Darrick Carter, Philip L. Felgner, D. Huw Davies
Published 2018-12-01

Development of a biomarker mortality risk model in acute respiratory distress syndrome

by Christian Bime, Nancy Casanova, Radu C. Oita, Juliet Ndukum, Heather Lynn, Sara M. Camp, Yves Lussier, Ivo Abraham, Darrick Carter, Edmund J. Miller, Armand Mekontso-Dessap, Charles A. Downs, Joe G. N. Garcia
Published 2019-12-01

Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant.

by Rhea N Coler, Sylvie Bertholet, Magdalini Moutaftsi, Jeff A Guderian, Hillarie Plessner Windish, Susan L Baldwin, Elsa M Laughlin, Malcolm S Duthie, Christopher B Fox, Darrick Carter, Martin Friede, Thomas S Vedvick, Steven G Reed
Published 2011-01-01

Process Development of Sj-p80: A Low-Cost Transmission-Blocking Veterinary Vaccine for Asiatic Schistosomiasis

by Adebayo J. Molehin, Adebayo J. Molehin, Sean A. Gray, Cheri Turner, Jennifer Davis, Weidong Zhang, Weidong Zhang, Sabiha Khatoon, Sabiha Khatoon, Madison Rattan, Rebecca Kernen, Christopher Peterson, Souad R. Sennoune, Darrick Carter, Afzal A. Siddiqui, Afzal A. Siddiqui
Published 2021-02-01

Fifteen Years of Sm-p80-Based Vaccine Trials in Nonhuman Primates: Antibodies From Vaccinated Baboons Confer Protection in vivo and in vitro From Schistosoma mansoni and Identifica...

by Weidong Zhang, Weidong Zhang, Loc Le, Loc Le, Gul Ahmad, Adebayo J. Molehin, Adebayo J. Molehin, Arif J. Siddiqui, Workineh Torben, Souvik Karmakar, Juan U. Rojo, Souad Sennoune, Souad Sennoune, Samara Lazarus, Samara Lazarus, Sabiha Khatoon, Sabiha Khatoon, Jasmin Freeborn, Jasmin Freeborn, Justin Sudduth, Justin Sudduth, Ashraf F. Rezk, Ashraf F. Rezk, David Carey, Roman F. Wolf, Roman F. Wolf, James F. Papin, Ray Damian, Sean A. Gray, Florian Marks, Florian Marks, Darrick Carter, Darrick Carter, Afzal A. Siddiqui, Afzal A. Siddiqui
Published 2020-06-01

Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study.

by Catherine A Cosgrove, Charles J Lacey, Alethea V Cope, Angela Bartolf, Georgina Morris, Celine Yan, Susan Baden, Tom Cole, Darrick Carter, Elizabeth Brodnicki, Xiaoying Shen, Sarah Joseph, Stephen C DeRosa, Lili Peng, Xuesong Yu, Guido Ferrari, Mike Seaman, David C Montefiori, Nicole Frahm, Georgia D Tomaras, Wolfgang Stöhr, Sheena McCormack, Robin J Shattock
Published 2016-01-01