LASSBio-897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A2A Receptor

LASSBio-897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A2A Receptor

Silicosis is a lethal fibro-granulomatous pulmonary disease highly prevalent in developing countries, for which no proper therapy is available. Among a small series of N-acylhydrazones, the safrole-derived compound LASSBio-897 (3-thienylidene-3, 4-methylenedioxybenzoylhydrazide) raised interest due...

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Bibliographic Details
Main Authors: Vinicius F. Carvalho, Tatiana P. T. Ferreira, Ana C. S. de Arantes, François Noël, Roberta Tesch, Carlos M. R. Sant’Anna, Eliezer J. L. Barreiro, Carlos A. M. Fraga, Patrícia M. Rodrigues e Silva, Marco A. Martins
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
A2A receptor
cAMP
fibrosis
LASSBio-897
silicosis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00778/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00778/full

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