HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells.

HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells.

Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell responses towards virus-derived peptide/human leukocyte antigen (HLA) complexes provide the broadest cross-reactive immunity against human influenza viruses. Several univ...

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Bibliographic Details
Main Authors: Sneha Sant, Sergio M Quiñones-Parra, Marios Koutsakos, Emma J Grant, Thomas Loudovaris, Stuart I Mannering, Jane Crowe, Carolien E van de Sandt, Guus F Rimmelzwaan, Jamie Rossjohn, Stephanie Gras, Liyen Loh, Thi H O Nguyen, Katherine Kedzierska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008714

Internet

https://doi.org/10.1371/journal.ppat.1008714

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