Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, pot...

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Bibliographic Details
Main Authors: Jung-Hwan Kim, Tsutomu Matsubara, Jaekwon Lee, Cristina Fenollar-Ferrer, Kyungreem Han, Donghwan Kim, Shang Jia, Christopher J. Chang, Heejung Yang, Tomokazu Nagano, Kristopher W. Krausz, Sun-Hee Yim, Frank J. Gonzalez
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20461-0

Internet

https://doi.org/10.1038/s41467-020-20461-0

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