Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, pot...

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Main Authors:	Jung-Hwan Kim, Tsutomu Matsubara, Jaekwon Lee, Cristina Fenollar-Ferrer, Kyungreem Han, Donghwan Kim, Shang Jia, Christopher J. Chang, Heejung Yang, Tomokazu Nagano, Kristopher W. Krausz, Sun-Hee Yim, Frank J. Gonzalez
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20461-0

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spelling	doaj-4f6071cc15e246109373c004d13bfa3a2021-01-17T12:11:51ZengNature Publishing GroupNature Communications2041-17232021-01-0112111210.1038/s41467-020-20461-0Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasisJung-Hwan Kim0Tsutomu Matsubara1Jaekwon Lee2Cristina Fenollar-Ferrer3Kyungreem Han4Donghwan Kim5Shang Jia6Christopher J. Chang7Heejung Yang8Tomokazu Nagano9Kristopher W. Krausz10Sun-Hee Yim11Frank J. Gonzalez12Department of Pharmacology, School of Medicine, Institute of Health Sciences, Department of Convergence Medical Science, Gyeongsang National UniversityLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthDepartment of Biochemistry, University of Nebraska-LincolnLaboratory of Molecular & Cellular Neurobiology, National Institute of Mental Health, National Institutes of HealthLaboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of HealthLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthDepartments of Chemistry and Molecular and Cell Biology, University of CaliforniaDepartments of Chemistry and Molecular and Cell Biology, University of CaliforniaLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of HealthThe environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effects on mitochondrial function.https://doi.org/10.1038/s41467-020-20461-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jung-Hwan Kim Tsutomu Matsubara Jaekwon Lee Cristina Fenollar-Ferrer Kyungreem Han Donghwan Kim Shang Jia Christopher J. Chang Heejung Yang Tomokazu Nagano Kristopher W. Krausz Sun-Hee Yim Frank J. Gonzalez
spellingShingle	Jung-Hwan Kim Tsutomu Matsubara Jaekwon Lee Cristina Fenollar-Ferrer Kyungreem Han Donghwan Kim Shang Jia Christopher J. Chang Heejung Yang Tomokazu Nagano Kristopher W. Krausz Sun-Hee Yim Frank J. Gonzalez Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis Nature Communications
author_facet	Jung-Hwan Kim Tsutomu Matsubara Jaekwon Lee Cristina Fenollar-Ferrer Kyungreem Han Donghwan Kim Shang Jia Christopher J. Chang Heejung Yang Tomokazu Nagano Kristopher W. Krausz Sun-Hee Yim Frank J. Gonzalez
author_sort	Jung-Hwan Kim
title	Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
title_short	Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
title_full	Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
title_fullStr	Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
title_full_unstemmed	Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
title_sort	lysosomal slc46a3 modulates hepatic cytosolic copper homeostasis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effects on mitochondrial function.
url	https://doi.org/10.1038/s41467-020-20461-0
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Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

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