Simultaneous Induction of Glycolysis and Oxidative Phosphorylation during Activation of Hepatic Stellate Cells Reveals Novel Mitochondrial Targets to Treat Liver Fibrosis

Simultaneous Induction of Glycolysis and Oxidative Phosphorylation during Activation of Hepatic Stellate Cells Reveals Novel Mitochondrial Targets to Treat Liver Fibrosis

Upon liver injury, hepatic stellate cells (HSCs) transdifferentiate to migratory, proliferative and extracellular matrix-producing myofibroblasts (e.g., activated HSCs; aHSCs) causing liver fibrosis. HSC activation is associated with increased glycolysis and glutaminolysis. Here, we compared the con...

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Bibliographic Details
Main Authors: Natalia Smith-Cortinez, Karen van Eunen, Janette Heegsma, Sandra Alejandra Serna-Salas, Svenja Sydor, Lars P. Bechmann, Han Moshage, Barbara M. Bakker, Klaas Nico Faber
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
cell metabolism
liver fibrosis
mitochondria
Online Access:https://www.mdpi.com/2073-4409/9/11/2456

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