A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity

A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity

Emerging evidence has suggested that aldosterone has direct deleterious effects on the kidney independently of its hemodynamic effects. However, the detailed mechanisms of these direct effects remain to be elucidated. We have previously reported that camostat mesilate (CM), a synthetic serine protea...

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Bibliographic Details
Main Authors: Yutaka Kakizoe, Yoshikazu Miyasato, Tomoaki Onoue, Terumasa Nakagawa, Manabu Hayata, Kohei Uchimura, Jun Morinaga, Teruhiko Mizumoto, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Kimio Tomita, Masashi Mukoyama, Kenichiro Kitamura
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Journal of Pharmacological Sciences
Subjects:
Aldosterone
Kidney injury
Serine protease
Plasmin
Serine protease inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131630130X

Internet

http://www.sciencedirect.com/science/article/pii/S134786131630130X

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