Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study.

A meta-analysis combining results from three genome-wide association studies and followed by large-scale replication identified six novel type 2 diabetes loci. Subsequent studies of the effect of these variants on estimates of the beta-cell function and insulin sensitivity have been inconclusive. We...

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Main Authors: Trine Welløv Boesgaard, Anette Prior Gjesing, Niels Grarup, Jarno Rutanen, Per-Anders Jansson, Marta Letizia Hribal, Giorgio Sesti, Andreas Fritsche, Norbert Stefan, Harald Staiger, Hans Häring, Ulf Smith, Markku Laakso, Oluf Pedersen, Torben Hansen, EUGENE2 Consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2747270?pdf=render