Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

Cytokines and chemokines are produced and secreted by a broad range of immune cells including macrophages. Remarkably, little is known about how these inflammatory mediators are released from the various immune cells. Here, the endolysosomal cation channel TRPML2 is shown to play a direct role in ch...

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Bibliographic Details
Main Authors: Eva Plesch, Cheng-Chang Chen, Elisabeth Butz, Anna Scotto Rosato, Einar K Krogsaeter, Hua Yinan, Karin Bartel, Marco Keller, Dina Robaa, Daniel Teupser, Lesca M Holdt, Angelika M Vollmar, Wolfgang Sippl, Rosa Puertollano, Diego Medina, Martin Biel, Christian Wahl-Schott, Franz Bracher, Christian Grimm
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
TRPML2
TRPML
lysosome
CCL2
macrophage
Mcoln2
Online Access:https://elifesciences.org/articles/39720

Internet

https://elifesciences.org/articles/39720

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