Reversal Effect of ALK Inhibitor NVP-TAE684 on ABCG2-Overexpressing Cancer Cells

Reversal Effect of ALK Inhibitor NVP-TAE684 on ABCG2-Overexpressing Cancer Cells

Failure of cancer chemotherapy is mostly due to multidrug resistance (MDR). Overcoming MDR mediated by overexpression of ATP binding cassette (ABC) transporters in cancer cells remains a big challenge. In this study, we explore whether NVP-TAE684, a novel ALK inhibitor which has the potential to inh...

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Bibliographic Details
Main Authors: Jingqiu Wang, Jing-Quan Wang, Chao-Yun Cai, Qingbin Cui, Yuqi Yang, Zhuo-Xun Wu, Xingduo Dong, Leli Zeng, Linguo Zhao, Dong-Hua Yang, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Oncology
Subjects:
NVP-TAE684
ATP-binding cassette (ABC) transporter
ABCG2
ALK inhibitor
multidrug resistance (MDR)
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00228/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00228/full

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