Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

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ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance on ATR for survival. Indeed, we observe that r...

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Bibliographic Details
Main Authors: Kumar Sanjiv, Anna Hagenkort, José Manuel Calderón-Montaño, Tobias Koolmeister, Philip M. Reaper, Oliver Mortusewicz, Sylvain A. Jacques, Raoul V. Kuiper, Niklas Schultz, Martin Scobie, Peter A. Charlton, John R. Pollard, Ulrika Warpman Berglund, Mikael Altun, Thomas Helleday
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Cell Reports
Subjects:
ATR
CHK1
synthetic lethality
cancer
DNA damage
replication stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715014564

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http://www.sciencedirect.com/science/article/pii/S2211124715014564

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