A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1

A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1

Recent studies indicate that soluble oligomers drive pathogenesis in several neurodegenerative proteinopathies, including Alzheimer and Parkinson disease. Curiously, the same conformational antibody recognizes different disease-related oligomers, despite the variations in clinical presentation and b...

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Bibliographic Details
Main Authors: Cristian A Lasagna-Reeves, Maxime WC Rousseaux, Marcos J Guerrero-Muñoz, Jeehye Park, Paymaan Jafar-Nejad, Ronald Richman, Nan Lu, Urmi Sengupta, Alexandra Litvinchuk, Harry T Orr, Rakez Kayed, Huda Y Zoghbi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-05-01
Series:eLife
Subjects:
ataxin-1
amyloid oligomer
native interactor
proteinopathies
Online Access:https://elifesciences.org/articles/07558

Internet

https://elifesciences.org/articles/07558

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