Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation

Hypoxia and inflammation are closely intertwined phenomena. Critically ill patients often suffer from systemic inflammatory conditions and concurrently experience short-lived hypoxia. We evaluated the effects of short-term hypoxia on systemic inflammation, and show that it potently attenuates pro-in...

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Bibliographic Details
Main Authors: Dorien Kiers, Ben Wielockx, Esther Peters, Lucas T. van Eijk, Jelle Gerretsen, Aaron John, Emmy Janssen, Rianne Groeneveld, Mara Peters, Lars Damen, Ana M. Meneses, Anja Krüger, Jeroen D. Langereis, Aldert L. Zomer, Michael R. Blackburn, Leo A. Joosten, Mihai G. Netea, Niels P. Riksen, Johannes G. van der Hoeven, Gert-Jan Scheffer, Holger K. Eltzschig, Peter Pickkers, Matthijs Kox
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418302287

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http://www.sciencedirect.com/science/article/pii/S2352396418302287

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