Elimination of SHIV Infected Cells by Combinations of Bispecific HIVxCD3 DART® Molecules

Elimination of SHIV Infected Cells by Combinations of Bispecific HIVxCD3 DART® Molecules

Bispecific HIVxCD3 DART molecules that co-engage the viral envelope glycoprotein (Env) on HIV-1-infected cells and the CD3 receptor on CD3+ T cells are designed to mediate the cytolysis of HIV-1-infected, Env-expressing cells. Using a novel ex vivo system with cells from rhesus macaques (RMs) infect...

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Bibliographic Details
Main Authors: Marina Tuyishime, Amir Dashti, Katelyn Faircloth, Shalini Jha, Jeffrey L. Nordstrom, Barton F. Haynes, Guido Silvestri, Ann Chahroudi, David M. Margolis, Guido Ferrari
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
HIV
bispecific DART molecules
redirected cytotoxicity
cytotoxic T cells
broadly neutralizing antibodies
non-neutralizing antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.710273/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.710273/full

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