Computational Structure-Based De Novo Design of Hypothetical Inhibitors against the Anti- Inflammatory Target COX-2.

Computational Structure-Based De Novo Design of Hypothetical Inhibitors against the Anti- Inflammatory Target COX-2.

Cyclooxygenase-2 (COX-2) produces prostaglandins in inflamed tissues and hence has been considered as an important target for the development of anti-inflammatory drugs since long. Administration of traditional non-steroidal anti-inflammatory drugs (NSAIDs) and other COX-2 selective inhibitors (COXI...

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Bibliographic Details
Main Authors: Jaspreet Kaur Dhanjal, Anith Kumar Sreenidhi, Khushboo Bafna, Shashank Prakash Katiyar, Sukriti Goyal, Abhinav Grover, Durai Sundar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4524694?pdf=render

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http://europepmc.org/articles/PMC4524694?pdf=render

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