RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development

RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development

The characterization of prostate epithelial hierarchy and lineage heterogeneity is critical to understand its regenerative properties and malignancies. Here, we report that the transcription factor RUNX1 marks a specific subpopulation of proximal luminal cells (PLCs), enriched in the periurethral re...

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Bibliographic Details
Main Authors: Renaud Mevel, Ivana Steiner, Susan Mason, Laura CA Galbraith, Rahima Patel, Muhammad ZH Fadlullah, Imran Ahmad, Hing Y Leung, Pedro Oliveira, Karen Blyth, Esther Baena, Georges Lacaud
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
RUNX1
prostate
development
proximal luminal cells
intrinsic castration-resistance
single-cell RNA-seq
Online Access:https://elifesciences.org/articles/60225

Internet

https://elifesciences.org/articles/60225

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