Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain)

Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain)

Abstract Background Schistosoma mekongi, which causes schistosomiasis in humans, is an important public health issue in Southeast Asia. Treatment with praziquantel is the primary method of control but emergence of praziquantel resistance requires the development of alternative drugs and vaccines. Ca...

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Bibliographic Details
Main Authors: Salisa Chaimon, Yanin Limpanont, Onrapak Reamtong, Sumate Ampawong, Orawan Phuphisut, Phiraphol Chusongsang, Jiraporn Ruangsittichai, Usa Boonyuen, Dorn Watthanakulpanich, Anthony J. O’Donoghue, Conor R. Caffrey, Poom Adisakwattana
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Parasites & Vectors
Subjects:
Schistosoma mekongi
Schistosomiasis
Calcium-dependent cysteine protease
Calpain
Drug and vaccine development
Online Access:http://link.springer.com/article/10.1186/s13071-019-3639-9

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http://link.springer.com/article/10.1186/s13071-019-3639-9

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