Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells.

Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells.

Autophagy is a critical cellular process required for maintaining cellular homeostasis in health and disease states, but the molecular mechanisms and impact of autophagy on cancer is not fully understood. Here, we found that Sox2, a key transcription factor in the regulation of the "stemness&qu...

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Bibliographic Details
Main Authors: Yong-Yeon Cho, Dong Joon Kim, Hye Suk Lee, Chul-Ho Jeong, Eun-Jin Cho, Myong-Ok Kim, Sanguine Byun, Kun-Yeong Lee, Ke Yao, Andria Carper, Alyssa Langfald, Ann M Bode, Zigang Dong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3581442?pdf=render

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http://europepmc.org/articles/PMC3581442?pdf=render

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