CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities

CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities

Help from CD4+ T cells is important to induce CD8+ T cell memory responses, but mechanistic insights are lacking. Here, the authors show, by transcriptomics and epigenetics, how CD4+ T cells help program memory CD8+ T cells for help-independent recall by antigens, as well as for innate-like recall r...

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Bibliographic Details
Main Authors: Tomasz Ahrends, Julia Busselaar, Tesa M. Severson, Nikolina Bąbała, Evert de Vries, Astrid Bovens, Lodewyk Wessels, Fred van Leeuwen, Jannie Borst
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13438-1

Internet

https://doi.org/10.1038/s41467-019-13438-1

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