Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

Background: Docosahexaenoic acid (DHA), a key lipid in nervous system homeostasis, is depleted in the spinal cord of sporadic amyotrophic lateral sclerosis (sALS) patients. However, the basis for such loss was unknown. Methods: DHA synthetic machinery was evaluated in spinal cord samples from ALS pa...

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Main Authors: Daniel Cacabelos, Victòria Ayala, Ana Belén Granado-Serrano, Mariona Jové, Pascual Torres, Jordi Boada, Rosanna Cabré, Omar Ramírez-Núñez, Hugo Gonzalo, Aranzazu Soler-Cantero, José Carlos Enrique Serrano, Maria Josep Bellmunt, María Paz Romero, María José Motilva, Takashi Nonaka, Masato Hasegawa, Isidre Ferrer, Reinald Pamplona, Manuel Portero-Otín
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Neurobiology of Disease
Subjects:
Motor neuron
Lipidomic
Oxidative stress
TDP-43
Polyunsaturated fatty acids
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300080

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http://www.sciencedirect.com/science/article/pii/S0969996116300080

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