NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma

NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma

Abstract Background Acute glaucoma, characterized by a sudden elevation in intraocular pressure (IOP) and retinal ganglion cells (RGCs) death, is a major cause of irreversible blindness worldwide that lacks approved effective therapies, validated treatment targets and clear molecular mechanisms. We...

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Bibliographic Details
Main Authors: Hui Chen, Yang Deng, Xiaoliang Gan, Yonghao Li, Wenyong Huang, Lin Lu, Lai Wei, Lishi Su, Jiawen Luo, Bin Zou, Yanhua Hong, Yihai Cao, Yizhi Liu, Wei Chi
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Molecular Neurodegeneration
Subjects:
Acute glaucoma
pyroptosis
NOD-like receptor 12
caspase-8/ HIF-1α
Online Access:http://link.springer.com/article/10.1186/s13024-020-00372-w

Internet

http://link.springer.com/article/10.1186/s13024-020-00372-w

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