TLR-3 is present in human adipocytes, but its signalling is not required for obesity-induced inflammation in adipose tissue in vivo.

TLR-3 is present in human adipocytes, but its signalling is not required for obesity-induced inflammation in adipose tissue in vivo.

Innate immunity plays a pivotal role in obesity-induced low-grade inflammation originating from adipose tissue. Key receptors of the innate immune system including Toll-like receptors-2 and -4 (TLRs) are triggered by nutrient excess to promote inflammation. The role of other TLRs in this process is...

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Bibliographic Details
Main Authors: Dov B Ballak, Edwin J P van Asseldonk, Janna A van Diepen, Henry Jansen, Anneke Hijmans, Leo A B Joosten, Cees J Tack, Mihai G Netea, Rinke Stienstra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4395029?pdf=render

Internet

http://europepmc.org/articles/PMC4395029?pdf=render

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