mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress – An experimental and modeling study

mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress – An experimental and modeling study

Unfolded or misfolded proteins in the endoplasmic reticulum (ER) trigger an adaptive ER stress response known as unfolded protein response (UPR). Depending on the severity of ER stress, either autophagy-controlled survival or apoptotic cell death can be induced. The molecular mechanisms by which UPR...

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Bibliographic Details
Main Authors: Orsolya Kapuy, P.K. Vinod, Gábor Bánhegyi
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Autophagy
Apoptosis
Endoplasmic reticulum stress
Metyrapone
Unfolded protein response
mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000710

Internet

http://www.sciencedirect.com/science/article/pii/S2211546314000710

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