Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis

Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis

Abstract The neuronal ceroid lipofuscinoses (NCLs) are the most common cause of childhood dementia and are invariably fatal. Early localized glial activation occurs in these disorders, and accurately predicts where neuronal loss is most pronounced. Recent evidence suggests that glial dysfunction may...

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Bibliographic Details
Main Authors: Jenny Lange, Luke J. Haslett, Emyr Lloyd-Evans, Jennifer M. Pocock, Mark S. Sands, Brenda P. Williams, Jonathan D. Cooper
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Acta Neuropathologica Communications
Subjects:
Infantile batten disease, CLN1 disease, neuronal ceroid lipofuscinosis
Neuron-glial interactions
Astrocyte and microglial dysfunction
Online Access:http://link.springer.com/article/10.1186/s40478-018-0575-4

Internet

http://link.springer.com/article/10.1186/s40478-018-0575-4

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