Anti-cadherin-17 antibody modulates beta-catenin signaling and tumorigenicity of hepatocellular carcinoma.

Anti-cadherin-17 antibody modulates beta-catenin signaling and tumorigenicity of hepatocellular carcinoma.

Cadherin-17 (CDH17) is an oncofetal molecule associated with poor prognostic outcomes of hepatocellular carcinoma (HCC), for which the treatment options are very limited. The present study investigates the therapeutic potential of a monoclonal antibody (Lic5) that targets the CDH17 antigen in HCC. I...

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Bibliographic Details
Main Authors: Yonggang Wang, Felix H Shek, Kwong F Wong, Ling Xiao Liu, Xiao Qian Zhang, Yi Yuan, Ester Khin, Mei-Yu Hu, Jian Hua Wang, Ronnie T P Poon, Wanjin Hong, Nikki P Lee, John M Luk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3770615?pdf=render

Internet

http://europepmc.org/articles/PMC3770615?pdf=render

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