Heterosubtypic antiviral activity of hemagglutinin-specific antibodies induced by intranasal immunization with inactivated influenza viruses in mice.

Heterosubtypic antiviral activity of hemagglutinin-specific antibodies induced by intranasal immunization with inactivated influenza viruses in mice.

Influenza A virus subtypes are classified on the basis of the antigenicity of their envelope glycoproteins, hemagglutinin (HA; H1-H17) and neuraminidase. Since HA-specific neutralizing antibodies are predominantly specific for a single HA subtype, the contribution of antibodies to the heterosubtypic...

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Bibliographic Details
Main Authors: Mieko Muramatsu, Reiko Yoshida, Hiroko Miyamoto, Daisuke Tomabechi, Masahiro Kajihara, Junki Maruyama, Takashi Kimura, Rashid Manzoor, Kimihito Ito, Ayato Takada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3745432?pdf=render

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http://europepmc.org/articles/PMC3745432?pdf=render

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