Exome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS)

Exome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS)

Abstract Background Serrated or Hyperplastic Polyposis Syndrome (SPS, HPS) is a yet poorly defined colorectal cancer (CRC) predisposition characterised by the occurrence of multiple and/or large serrated polyps throughout the colon. A serrated polyp-CRC sequence (serrated pathway) of CRC formation h...

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Bibliographic Details
Main Authors: Sukanya Horpaopan, Jutta Kirfel, Sophia Peters, Michael Kloth, Robert Hüneburg, Janine Altmüller, Dmitriy Drichel, Margarete Odenthal, Glen Kristiansen, Christian Strassburg, Jacob Nattermann, Per Hoffmann, Peter Nürnberg, Reinhard Büttner, Holger Thiele, Philip Kahl, Isabel Spier, Stefan Aretz
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Hereditary Cancer in Clinical Practice
Subjects:
Familial colorectal cancer (CRC)
Exome sequencing
Hyperplastic polyposis syndrome (HPS)
Serrated polyposis syndrome (SPS)
Serrated pathway
Somatic mutations
Online Access:http://link.springer.com/article/10.1186/s13053-017-0082-9

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http://link.springer.com/article/10.1186/s13053-017-0082-9

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