Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells.

Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells.

Glucocorticoids (GCs) selectively trigger cell death in the multiple myeloma cell line MM1S which express NR3C1/Glucocorticoid Receptor (GR) protein, but fail to kill MM1R cells which lack GR protein. Given recent demonstrations of altered microRNA profiles in a diverse range of haematological malig...

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Bibliographic Details
Main Authors: Ajay Palagani, Ken Op de Beeck, Stefan Naulaerts, Jolien Diddens, Chandra Sekhar Chirumamilla, Guy Van Camp, Kris Laukens, Karen Heyninck, Sarah Gerlo, Pieter Mestdagh, Joke Vandesompele, Wim Vanden Berghe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4256227?pdf=render

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http://europepmc.org/articles/PMC4256227?pdf=render

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