Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity.

The role of mast cells (MCs) in contact hypersensitivity (CHS) remains controversial. This is due in part to the use of the MC-deficient Kit (W/Wv) mouse model, since Kit (W/Wv) mice congenitally lack other types of cells as a result of a point mutation in c-kit. A recent study indicated that the in...

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Main Authors: Atsushi Otsuka, Masato Kubo, Tetsuya Honda, Gyohei Egawa, Saeko Nakajima, Hideaki Tanizaki, Bongju Kim, Satoshi Matsuoka, Takeshi Watanabe, Susumu Nakae, Yoshiki Miyachi, Kenji Kabashima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21980488/?tool=EBI