MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells

MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells

MAPK-activated protein kinase 2 (MK2) has diverse roles in cancer. In response to chemotherapy, MK2 inhibition is synthetically lethal to p53-deficiency. While <i>TP53</i> deletion is rare in glioblastomas, these tumors often carry <i>TP53</i> mutations. Here, we show that MK...

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Bibliographic Details
Main Authors: Athena F. Phoa, Ariadna Recasens, Fadi M. S. Gurgis, Tara A. Betts, Sharleen V. Menezes, Diep Chau, Kristiina Nordfors, Joonas Haapasalo, Hannu Haapasalo, Terrance G. Johns, Brett W. Stringer, Bryan W. Day, Michael E. Buckland, Najoua Lalaoui, Lenka Munoz
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
glioblastoma
mk2
p53
senescence
temozolomide
Online Access:https://www.mdpi.com/2072-6694/12/3/654

Internet

https://www.mdpi.com/2072-6694/12/3/654

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