Targeting EZH2 in Multiple Myeloma—Multifaceted Anti-Tumor Activity
The enhancer of zeste homolog 2 (EZH2) is the enzymatic subunit of the polycomb repressive complex 2 (PRC2) that exerts important functions during normal development as well as disease. PRC2 through EZH2 tri-methylates histone H3 lysine tail residue 27 (H3K27me3), a modification associated with repr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-09-01
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| Series: | Epigenomes |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-4655/2/3/16 |