Targeting EZH2 in Multiple Myeloma—Multifaceted Anti-Tumor Activity

by Mohammad Alzrigat, Helena Jernberg-Wiklund, Jonathan D. Licht
Published 2018-09-01

Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis.

by Kelly M Arcipowski, Marinka Bulic, Sandeep Gurbuxani, Jonathan D Licht
Published 2016-01-01

The role of sex and rurality in cancer fatalistic beliefs and cancer screening utilization in Florida

by Yi Guo, Sarah M. Szurek, Jiang Bian, Dejana Braithwaite, Jonathan D. Licht, Elizabeth A. Shenkman
Published 2021-09-01

Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1.

by Sam Collins, Adam Waickman, Albert Basson, Abraham Kupfer, Jonathan D Licht, Maureen R Horton, Jonathan D Powell
Published 2012-01-01

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

by Jung Kim, Yongik Lee, Xiaodong Lu, Bing Song, Ka-Wing Fong, Qi Cao, Jonathan D. Licht, Jonathan C. Zhao, Jindan Yu
Published 2018-12-01

Kidney development in the absence of Gdnf and Spry1 requires Fgf10.

by Odyssé Michos, Cristina Cebrian, Deborah Hyink, Uta Grieshammer, Linda Williams, Vivette D'Agati, Jonathan D Licht, Gail R Martin, Frank Costantini
Published 2010-01-01

FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

by Yue Sheng, Chunjie Yu, Yin Liu, Chao Hu, Rui Ma, Xinyan Lu, Peng Ji, Jianjun Chen, Benjamin Mizukawa, Yong Huang, Jonathan D. Licht, Zhijian Qian
Published 2020-02-01

A Pathologic Link between Wilms Tumor Suppressor Gene, WT1, and IFI16

by Marianne K-H. Kim, Jacqueline M. Mason, Chi-Ming Li, Windy Berkofsky-Fessler, Le Jiang, Divaker Choubey, Paul E. Grundy, Benjamin Tycko, Jonathan D. Licht
Published 2008-01-01

Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape

by Behnam Nabet, Pilib Ó Broin, Jaime M. Reyes, Kevin Shieh, Charles Y. Lin, Christine M. Will, Relja Popovic, Teresa Ezponda, James E. Bradner, Aaron A. Golden, Jonathan D. Licht
Published 2015-08-01

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition

by Teresa Ezponda, Daphné Dupéré-Richer, Christine M. Will, Eliza C. Small, Nobish Varghese, Tej Patel, Behnam Nabet, Relja Popovic, Jon Oyer, Marinka Bulic, Yupeng Zheng, Xiaoxiao Huang, Mrinal Y. Shah, Sayantan Maji, Alberto Riva, Manuela Occhionorelli, Giovanni Tonon, Neil Kelleher, Jonathan Keats, Jonathan D. Licht
Published 2017-10-01

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.

by Relja Popovic, Eva Martinez-Garcia, Eugenia G Giannopoulou, Quanwei Zhang, Qingyang Zhang, Teresa Ezponda, Mrinal Y Shah, Yupeng Zheng, Christine M Will, Eliza C Small, Youjia Hua, Marinka Bulic, Yanwen Jiang, Matteo Carrara, Raffaele A Calogero, William L Kath, Neil L Kelleher, Ji-Ping Wang, Olivier Elemento, Jonathan D Licht
Published 2014-09-01

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia

by Barry M. Zee, Kamrine E. Poels, Cong-Hui Yao, Kimihito C. Kawabata, Gongwei Wu, Cihangir Duy, William D. Jacobus, Elizabeth Senior, Jennifer E. Endress, Ashwini Jambhekar, Scott B. Lovitch, Jiexian Ma, Abhinav Dhall, Isaac S. Harris, M. Andres Blanco, David B. Sykes, Jonathan D. Licht, David M. Weinstock, Ari Melnick, Marcia C. Haigis, Franziska Michor, Yang Shi
Published 2021-06-01

DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

by Raajit Rampal, Altuna Alkalin, Jozef Madzo, Aparna Vasanthakumar, Elodie Pronier, Jay Patel, Yushan Li, Jihae Ahn, Omar Abdel-Wahab, Alan Shih, Chao Lu, Patrick S. Ward, Jennifer J. Tsai, Todd Hricik, Valeria Tosello, Jacob E. Tallman, Xinyang Zhao, Danette Daniels, Qing Dai, Luisa Ciminio, Iannis Aifantis, Chuan He, Francois Fuks, Martin S. Tallman, Adolfo Ferrando, Stephen Nimer, Elisabeth Paietta, Craig B. Thompson, Jonathan D. Licht, Christopher E. Mason, Lucy A. Godley, Ari Melnick, Maria E. Figueroa, Ross L. Levine
Published 2014-12-01