Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis

Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis

Plasma membrane (PM) free cholesterol (FC) is emerging as an important modulator of signal transduction. Here, we show that hepatocyte-specific knockout (HSKO) of the cellular FC exporter, ATP-binding cassette transporter A1 (ABCA1), leads to decreased PM FC content and defective trafficking of lyso...

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Bibliographic Details
Main Authors: Chia-Chi C. Key, Mingxia Liu, C. Lisa Kurtz, Soonkyu Chung, Elena Boudyguina, Timothy A. Dinh, Alexander Bashore, Peter E. Phelan, Barry I. Freedman, Timothy F. Osborne, Xuewei Zhu, Lijun Ma, Praveen Sethupathy, Sudha B. Biddinger, John S. Parks
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
hepatosteatosis
cholesterol
lipid raft
vesicle trafficking
selective insulin resistance
mTORC
plasma membrane
hepatocyte
Western-type diet
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306745

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http://www.sciencedirect.com/science/article/pii/S2211124717306745

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