Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure

Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure

Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), an endothelial cell protein, binds LPL in the subendothelial spaces and transports it to the capillary lumen. In Gpihbp1−/− mice, LPL remains stranded in the subendothelial spaces, causing hypertriglyceridemi...

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Bibliographic Details
Main Authors: Mikael Larsson, Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Rosemary L. Walzem, Anne P. Beigneux, Stephen G. Young, Loren G. Fong
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Journal of Lipid Research
Subjects:
glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1
lipoprotein lipase
triglyceride metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520339213

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520339213

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